CBDV: What Is It? Is It Superior To CBD?

Cannabidivarian, or CBDV, is a non-psychotropic analogue of cannabidiol (CBD), one of the primary cannabinoids. Because of their striking chemical similarities, CBDV and CBD can occasionally be hard to distinguish in laboratory testing.

The three-dimensional arrangement of the atoms in the two compounds is different, although having the identical chemical formula and seven double bond isomers.

The amounts of CBD and CBDV in the cannabis plant are the main distinctions between them. High-quality full spectrum and broad spectrum extracts that contribute to the entourage effect include trace levels of CBDV.

While CBDV is present in extremely minute amounts in cannabis, CBD is one of the most prevalent chemicals in the plant. There aren’t as many high CBDV strains or CBDV-specific products on the market as there are for many other minor cannabinoids that are rapidly gaining popularity (CBN, CBG, and CBC), but that doesn’t mean that CBDV shouldn’t be given attention, since the majority of research on the potential medical benefits centres around CBD and THC (tetrahydrocannabinol).

Particularly, GW Pharmaceuticals, a pharmaceutical corporation, has provided significant funding for CBDV research. According to these investigations, CBDV and CBD have some neuroprotective qualities as well as very comparable potential therapeutic benefits as an anticonvulsant, mood stabiliser, and anti-nausea agent.

We’ll examine the implications of the study for the use of CBDV in non-pharmaceutical contexts and its future prospects.

What advantages does CBDv offer?

There is little evidence for the possible therapeutic use of CBDV since the majority of cannabis research focuses on THC and CBD.

The only medication based on cannabis that has been authorised by the FDA at this time is called Epidiolex. This oral CBD solution, which is very concentrated, is recommended to treat severe types of epilepsy.

For more than 10 years, GW Pharmaceuticals, the pharmaceutical firm that made Epidiolex, has been in the forefront of supporting research on CBDV and its possible therapeutic applications.

As of right now, neither CBDV nor any other small cannabinoid has received FDA approval for use as a remedy or cure for any illness. This is crucial to emphasise because, as more CBD companies enter the market for trace amounts of cannabis, the terminology used to describe their advantages often becomes hazy. The advantages of CBDV and other substances are often overstated without sufficient solid research to back them up.

Although the field of medical cannabis is still very young, the study appears to be promising. Consult your doctor before incorporating CBDV or any other cannabinoid into your routine, particularly if you are on medication or have an underlying medical condition.

Let’s examine a few recent research on CBDV and its possible medical applications.

Autism Spectrum Disorder (ASD) and CBDV

Research is now being done on CBDV as a possible therapy for symptoms associated with autism spectrum disorder (ASD).

The primary symptoms of ASD, a neurodevelopmental disorder, have no recognised treatment. Restricted interests, trouble interacting and communicating with others, and repetitive thinking and behaviour patterns are typical characteristics.

Children with this illness are usually diagnosed at the age of three. According to medical experts, some drugs used by pregnant women may potentially raise the likelihood of a child having autistic spectrum condition, in addition to hereditary factors.

Although studies are still in their infancy, CBDV seems to have promise in treating recurrent behavioural and communicative issues. According to one research, CBDV may help individuals experience less acute anxiety by raising GABA levels in the brain and triggering the neurotransmitter glutamate [2].

It has been discovered that CBD and brain function similarly. Researchers are still looking into the effects of CBDV on ASD since prefrontal GABA systems in ASD individuals did not react the same way as they did in “neurotypical” participants. Phase III clinical trials for the same CBDV study on autistic spectrum disorder are now being conducted.

Intractable Epilepsy and CBDV

Seizures caused by intractable epilepsy, also known as drug-resistant epileptic seizures, are difficult to control with medicine. Prior to the commercialization of Epidoliex for the treatment of seizures, GW Pharmaceuticals supported preclinical research into the anticonvulsant potential of CBDV. According to early research, CBDV’s anticonvulsant properties were comparable to those of CBD.

It is thought that CBD and CBDV desensitise the TRPV1 receptor, also known as the vanilloid receptor, which is why they have anti-epileptic effects. Numerous forms of seizures have been shown to be initiated and progressed by this receptor.

CBDV And Symptoms Of Nausea

Nausea is a well developed defence system of our body that helps us eliminate potentially toxic substances from our bodies, despite the fact that it is mainly painful and inconvenient. This system is often overridden by other lifestyle variables, such as stress or typical prescription side effects, which may, in extreme situations, impair our regular day-to-day functioning.

Duchenne Muscular Dystrophy (DMD) and CBDV

A dystrophin protein shortage, which compromises the integrity of muscle cells and causes progressive muscle degeneration leading to permanent skeletal muscle degeneration, is the underlying cause of Duchenne muscular dystrophy (DMD), a hereditary disorder.

The illness is still unknown, although steroidal medications and physical therapy may help manage symptoms.

In order to lessen inflammation and promote muscular function, the National Research Council in Italy looked at non-euphoric chemicals from cannabis plants, especially CBD, CBDV, and THCV.

Rett Syndrome (RTT) and CBDV

A uncommon neurological condition known as Rett Syndrome (RTT) is nearly exclusively diagnosed in females. It is brought on by a rare mutation in the MECP2 gene, which causes significant deficits such as loss of speech and motor coordination.

Since Rett syndrome sufferers exhibit many of the same symptoms as autistic persons, RTT is included as an autism spectrum condition in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) [6].

Since there is no known cure for Rett syndrome, current therapies aim to enhance the quality of life for people who have the condition by easing anxiety and social deficiency symptoms.

Is Cannabidiverin, or CBDV, Legal?

According to the 2018 Farm Bill, hemp plants and their derivatives with less than 0.3% THC by dry weight may be produced and sold in the United States. This includes CBDV.

Always consult an independent lab test when looking for high-CBDV cannabis strains or CBDV-specific goods to be sure the product is free from harmful impurities and comes from a legal hemp source.

Conclusion  

Even though research on CBDV’s possible medicinal uses seems promising, more work has to be done in this area.

Although CBDV-specific products and cannabis strains are available online and in certain headshops, none of these products have received FDA approval to treat any medical ailment. Similar to CBD, CBDV is thought to be very safe and well-tolerated, which is why many individuals have reported that using CBDV to support their health objectives has enhanced their quality of life.

It’s crucial to keep in mind that many CBDV products on the market make inflated claims about their health benefits without providing reliable scientific evidence. Read between the lines and realise that while this chemical may be beneficial in many ways, it is not a panacea. Before starting to use large amounts of any kind of cannabis, you should see your physician and make lifestyle adjustments.